Anti-inflammatory Tshuaj Cov Tshuaj Pirfenidone

Anti-inflammatory Drug Pirfenidone CAS 53179-13-8 Tshuaj Raws Li
Khoom Lub Npe: Pirfenidone
CAS: 53179-13-8
MF: C12H11NO
MW: 185.22
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Anti-inflammatory Drug Pirfenidone CAS 53179-13-8 Tshuaj Raws Li

Khoom Lub Npe: Pirfenidone
5-METHYL-1-PHENYL-1H-PYRIDIN-2-IB; 5-METHYL-1-PHENYL-2 (1H-5-Methyl-1-phenyl-2 ) -PYRIDINONE; 5-METHYL-1-PHENYL-2- (1H) -PYRIDONE; 5-Methyl-N-phenyl-2-1 H-pyridone; Pirfenidone kuj pom 5-Methyl-1-Phenyl-2 (1H) Pyridinone
CAS: 53179-13-8
MF: C12H11NO
MW: 185.22


Pirfenidone (PFD) yog ib hom tshiab ntawm pyridine ketones uas muaj cov kab mob sab nraud los tiv thaiv fibrotic, ua tau los tiv thaiv thiab rov qab tsim cov fibrosis thiab caws pliav. Nws nkag mus rau hauv kev ua lag luam hauv Shionogi, Nyij Pooj xyoo 2008 thiab tau pom zoo los ntawm Teb Chaws Asmeskas cov khoom noj thiab Tshuaj. Nws yog thawj cov tshuaj uas tau ploj mus los ntawm theem III kev soj ntsuam kev sim (nrog rau rov qab, randomized, thiab placebo-tswj) uas tau ua kom pom tias nws ua tau zoo ntawm kev kho idiopathic pulmonary fibrosis (IPF); Ntxiv mus, cov tshuaj muaj tus cwj pwm zoo nyob rau hauv kev kho qee yam kab mob fibrotic xws li kab mob hauv lub cev ntawm cov pob txha thiab kab mob hauv lub siab. Tsis tas li ntawd, nws tseem hais txog qhov kev tshawb fawb thib ob ntawm kev mob hauv lub raum (focal segmental glomerulosclerosis), hypertrophic cardiomyopathy, cov neeg laus kuv neurofibromatosis, cov tub ntxhais hluas kuv hom neurofibromatosis thiab plexiform neurofibromas, mob ntshav qab zib nrog rau kab mob hauv lub raum.


Pirfenidone Clinical daim ntawv thov

1. Idiopathic pulmonary fibrosis degeneration

Idiopathic pulmonary fibrosis (IPF) yog ib qho tsis paub, tsis muaj neeg raug mob thiab muaj peev xwm ua rau mob siab mob ntsws. Nyob rau tib lub sijhawm, PFD yog ib qho tshuaj tiv thaiv, cov tshuaj tiv thaiv fibrotic uas yuav siv tau rau kev kho mob ntawm IPF.
2. Mob Ntshav Fibrosis
3. Mob fibrosis kis mob
4. Ntau Sclerosis
Multiple sclerosis (MS) yog ib hom kab mob ntsws ntawm lub cev thiab muaj kev tiv thaiv kab mob thiab kev tua kab mob. Cov zwj ceeb ntsig txog nws yog kev ua kom muaj hlwb, mob caj dab cell, thiab endothelial cell thiab nce ntawm lymphocytes, thaum PDF muaj cov teeb meem ntawm inhibiting cell activation.
5. Myocardial fibrosis
Cov kab mob plawv xws li kub siab, mob plawv, thiab atrial fibrillation tuaj yeem ua rau cov hlab ntaws quav, ua rau mob loj hlob tuaj. Siv PDF rau kev kho mob ntawm cardiomyopathy los ntawm Duchenne muscular dystrophy muaj peev xwm inhibit myocardial fibrosis, txhim kho mob plawv. PFD tuaj yeem txo cov xwm txheej ntawm atrial fibrillation thiab cov kev hloov ntawm myocardial dhau los ntawm inhibiting fibrosis.
6. Cov kab mob neoplastic: neurofibroma, leiomyoma, thiab malignant gliomas.
7. Kev tiv thaiv ntawm fibrosis tom qab hloov hloov nruab nrog.
8. Rheumatoid kev mob caj dab.


DMHA / 1,5-Dimethylhexylamine

DMBA / 1,3-Dimethylbutylamine

DMAA / 1,3-Dimethylpentylamine

AMP Citrate / 1,3-dimethylbutylamine citrate

DMAE bitartrate / 2-Dimethylaminoethanol bitartrate ntsev

DNP / Sodium 2,4-dinitrophenate

Orlistat

Pregabalin

Methylamine hydrochloride

gamma-Butyrolactone / GBL

Isotretinoin

Phenacetin

Benzyl benzoate

Benzyl cawv

Ethyl Oleate

4-Acetamidophenol / Paracetamol

Guaiacol

Tranexamic acid / Amstat

Noopept

Adrafinil

Raloxifene hydrochloride

Synephrine hydrochloride

Lorcaserin hydrochloride hemihydrate

Triamcinolone acetonide acetate

Xylazine

Aniracetam

Piracetam

Oxiracetam

Pramiracetam

Fasoracetam

Triclosan

Ibuprofen

Captopril

Adrenosterone / 11-OXO

Androsterone

Pramipexole Hydrochloride

Carphedon

Lub Plaub Hlis (CC-10004) / Otezla


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