TUS NEEG MUAJ NEEG LUS PAPERS GDF-8 Gdf-8 Myostatin 1mg

Khoom txhawb:
Khoom Lub Npe: GDF 8 Hmoov 1mg / vial
Pharmaceutical Raw Materials High purity GDF-8 (myostatin)
Hom Lub Npe: SENDI
Ntim: 1 yawg / 10vials, 1mg / vial
Tsham tam sim no
Txhawb tshuaj

Lyophilized Bodybuilding Peptide GDF-8 Gdf-8 Myostatin 1mg

Khoom txhawb:
Khoom Lub Npe: GDF 8 Hmoov 1mg / vial
Pharmaceutical Raw Materials High purity GDF-8 (myostatin)
Hom Lub Npe: SENDI
Ntim: 1 yawg / 10vials, 1mg / vial
CAS Tsis yog: 901758-09-6
Molecular Formula: C221H366N72O67S
Daim ntawv thov: Pharmaceutical raw materials
Purity:> 99.0%


Cov lus piav qhia ntawm GDF-8:
Myostatin (tseem hu ua kev sib txawv ntawm kev loj hlob 8, txo GDF-8) yog ib cov tshuaj myokine, ib qho protein tsim thiab tso tawm los ntawm myocytes uas ua rau ntawm cov leeg hlwb 'autocrine kev ua haujlwm rau inhibit myogenesis: mob hlwb loj hlob thiab txawv. Hauv tib neeg nws yog encoded los ntawm MSTN noob. Myostatin yog ib txoj kev loj hlob txawv ntawm qhov sib txawv uas yog ib tug tswv cuab ntawm TGF beta protein ntau tsev neeg. Txhua yam tsis tuaj yeem siv cov tshuaj myostatin los kho nrog cov tshuaj uas thaiv qhov kev ua si ntawm myostatin muaj ntau dua cov leeg nqaij. Tsis tas li ntawd, cov neeg uas muaj kev hloov nyob rau hauv ob qho tib si luam ntawm cov noob myostatin muaj mob ntau dua cov leeg thiab muaj zog dua qub. Kev thaiv cov kev ua si ntawm myostatin yuav muaj kev siv tshuaj rau kev kho cov leeg mob cov kab mob xws li mob nqaij npog dystrophy.


GDF-8 Purity:
GDF-8 muaj peptide purity level uas tshaj 99.0% raws li tau txiav txim los ntawm HPLC.


GDF-8 Siv:
Cov noob genocods myostatin tau tshawb pom nyob hauv 1997 los ntawm cov kws kho mob caj dab Se-Jin Lee thiab Alexandra McPherron uas tau tsim muaj cov kabmob uas tsis muaj kabmob uas tsis muaj cov noob. Cov moldatin no "knockout" nas muaj li ntawm ob npaug ntawm cov leeg li cov nas tsuag. Cov nas tsuag tau tom qab npe hu ua "nas tsuag loj".

Qhov tseeb tshwm sim ntawm myostatin tau pom nyob rau hauv cov nyuj los ntawm Ravi Kambadur, whippets, thiab tib neeg; nyob rau hauv txhua qhov teeb meem qhov tshwm sim yog ib qho ua rau neeg mob loj zuj zus. Ib qho kev hloov nyob rau hauv 3 'UTR ntawm tus myostatin noob hauv Texel yaj ua ib qho chaw rau lub microRNAs miR-1 thiab miR-206. Qhov no yog yuav ua rau cov nqaij npau taws phenotype ntawm no yug ntawm cov yaj.

Human myostatin muaj ob qho tib si subunits, txhua yam muaj ntawm 109 (NCBI database cov neeg thov myostatin yog 375 residues ntev) cov amino acid residues. Nws cov nyhuv txhua qhov hnyav yog 25.0 kDa. Cov protein tsis ua haujlwm kom txog thaum lub protease cleaves NH2-qhov xaus, los yog "pro-sau" feem ntawm molecule, uas ua rau lub COOH-dav hlau khiav dim. Myostatin khi rau qhov activin type II receptor, uas ua rau ib tus neeg tau txais los ntawm tus neeg mob Alk-3 lossis Alk-4. Tus kab mob coreceptor no ces pib lub xov tooj ntawm tes taw rau hauv cov nqaij, uas muaj qhov ua kom muaj npe hauv SMAD tsev neeg - SMAD2 thiab SMAD3. Cov teebmeem no ces ua kom muaj kev paub txog cov qoob loo ntawm cov noob qes. Thaum ua ntawv thov rau myoblasts, myostatin txwv tsis pub lawv txawv hauv cov nqaij ntshiv ntawm cev nqaij daim tawv.

Myostatin tseem txwv tsis pub Akt, ib tug kinase uas txaus ua rau cov leeg hypertrophy, hauv ib feem los ntawm qhov ua kom muaj protein ntau synthesis. Txawm li cas los, Akt tsis yog lub luag hauj lwm rau tag nrho cov nqaij ntshiv uas pom tau los ntawm myostatin inhibition Li no myostatin ua rau ob txoj kev: los ntawm inhibiting leeg txawv, thiab los ntawm inhibiting Akt-vim tau protein ntau synthesis.

Cov kev tshawb fawb ntxiv rau hauv myostatin thiab cov noob myostatin kuj yuav ua rau kev kho mob rau cov nqaij npaws ntawm dystrophy. Lub tswv yim yog los ua kom paub cov tshuaj uas thaiv myostatin. Lub monoclonal antibody specific rau myostatin ua rau cov nqaij loj hauv cov nas thiab cov liab.

Txoj kev kho ob lub lis piam uas muaj cov nas tsuag nrog cov kab mob hauv lub cev IIB, ib qho molecule uas feem ntau sib txuas rau cov hlwb thiab khi rau myostatin, ua rau kom muaj zog ntau dua nqaij (li 60%). Nws xav hais tias kev txav ntawm myostatin mus rau lub cev yaj tawv nqaij ua reseptor tiv thaiv nws los ntawm interacting nrog lub cell-txua receptors.

Nws tseem tsis tshua paub meej txog seb puas muaj kev tu ncua mus ntev txog kev quav ntawm cov quav hniav uas muaj kev tiv thaiv ntawm cov tshuaj tiv thaiv myostatin lig, vim tias cov nqaij ntshiv hlwb qaug zog yuav ua rau cov kab mob qis dua. Raws li xyoo 2012, tsis muaj kev tiv thaiv kev noj tshuaj hauv kev quav yeeb tshuaj rau tib neeg yog hauv lub khw. Ib qho antibody genetically engineered rau neutralize myostatin, stamulumab, uas yog nyob hauv txoj kev loj hlob los ntawm cov tuam txhab uas muag Wyeth., Tsis nyob hauv txoj kev loj hlob. Qee cov neeg ncaws pob, xav ua kom lawv txhais tes rau ntawm cov yeeb tshuaj, tig mus rau hauv internet qhov chaw fake "myostatin blockers" tab tom muag.

Myostatin qib zoo tau zoo los ntawm creatine supplementation.
Inhibition of myostatin ua rau cov leeg hyperplasia thiab hypertrophy. Cov tshuaj tiv thaiv myostatin tuaj yeem txhim kho kev ua kis las ncaws pob thiab vim li no muaj kev txhawj xeeb rau cov neeg ua rau cov neeg ua si yuav raug ua phem hauv kev ua si. Txawm li cas los xij, cov kev tshawb fawb pom nyob rau hauv cov nas hais tias myostatin inhibition tsis ncaj nraim kom nce lub zog ntawm tus neeg mob leeg.


Vim li cas koom tes nrog peb?
Siab zoo nrog kev sib tw
1) Qhia lub pob hloov tshiab hauv ASAP, thiab yuav sim zoo tshaj thaum daws tau ntsib ntau yam teeb meem.
2) Peb yuav qhia koj cov zaub mov thiab cov lus qhia rau txhua hom steroid kom cov hmoov ua kua, thiab kua ua rau me nyuam tsis huv.


Peb muaj neeg thoob ntiaj teb
1) Kev pabcuam thiab kev nplua nuj ua rau cov qhua tuaj yeem ua haujlwm zoo thiab tso siab rau peb.
2) Cov khoom muaj nqis (xws li Anti Estrogen Steroids) thiab kev xa khoom ceev ceev raws li qhov lawv xav tau.
3) Cov kev lag luam tawm tswv yim thiab cov khoom lag luam yuav zoo siab, ua tau raws li tus neeg yuav tsum tau yog peb lub luag haujlwm.
4) Muaj txiaj ntsim zoo thiab sib tw ua kom tau qhov kev ntseeg siab thiab qhuas ntawm cov neeg nyob thoob plaws lub ntiaj teb.


Ceev ceev thiab muaj kev nyab xeeb
1) Pov npav tuaj yeem xa tawm hauv 24 xuab moos tom qab them nuj nqi.
2) Ntau hom kev thauj mus los rau koj xaiv, xws li EMS, FedEx, TNT, DHL, USP.
3) Peb muaj peb tus neeg sawv cev uas tuaj yeem pab peb xa peb cov khoom kom sai thiab muaj kev ruaj ntseg, thiab peb muaj cov khoom lag luam txaus rau kev xa mus.
4) Peb muaj qhov tshwj xeeb txoj kev yuav nkoj 10g rau cov khoom hnyav khoom hnyav ib zaug. Peb muab cov hmoov yaj rau hauv cov dej ua kua. Thiab nkoj cov kua hauv cov pob tshwj xeeb.
5) Nrhiav tus xovtooj tshiab rau koj xyuas.


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Siab zoo nrog kev sib tw
Peb yog cov chaw tsim tshuaj thiab muab tau cov khoom zoo nrog cov khoom sib tw, muab pub dawb kuaj tag nrho, ob peb shipping nqi xwb.

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